The tenth 21c Museum Hotel occupies a 1926 former YMCA on Locust Street, pairing a boutique hotel with public contemporary art galleries. The restoration kept the wood paneled lounges, billiard room, and basement lap pool with its surviving Swim for Life mosaic, alongside the Idol Wolf restaurant.

Sassafras Cafe is the main restaurant at the Missouri Botanical Garden. The daylit dining room opens to a tree-lined patio. Nine panels of pressed plant specimens set in glass and resin divide the seating areas, alongside a communal oak bench.